article posted 20 June 2016
Professor Robert Hill is a Materials Engineer/Glass Scientist. He has published over 200 papers and 20 patents. He is Research Director at Dental Institute at Queen Mary and formerly Professor of Biomaterials at Imperial. He is an expert on degradable glasses and specializes in materials for hard tissue restoration and substitution. He is particularly interested in the relationships between glass structure and properties. He has a successful track record of taking his research from the laboratory into commercial products and examples include: Glass ionomer cements including Serenocem® used in ENT surgery, Ultradex® a nano-hydroxyapatite toothpaste sold in Boots and other pharmacies and more recently BioMinF® a fluoride containing bioactive glass toothpaste.
In 2013 he won the Amourers and Brasiers Venture Prize and has used the prize money to set up BioMin Technologies Ltd (see www.Biomin.co.uk) a Queen Mary Start up Company. The company is based on three bioactive glass patents owned by Imperial and Queen Mary. The first product from the company on sale is the BioMinF® toothpaste.
New Halogen Containing Bioactive Glasses For Use as A Toothpaste Additives
Unit of Dental Physical Sciences, Centre for Oral Growth and Development, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London
Bioactive glasses dissolve in body fluids release calcium and phosphate ions and form hydroxycarbonated apatite. Recently bioactive glasses have been used as an
additive for re-mineralizing and sensitivity toothpastes, such as Sensodyne Repair and Protect™. This paper investigates the dissolution behaviour of a high phosphate
fluoride containing bioactive glass termed BioMinF™ for use as a toothpaste additive. This glass dissolves releasing fluoride ions in addition to calcium and phosphate.
It forms fluoridated apatite as opposed to hydroxycarbonated apatite, which is particularly beneficial in dental applications. The solubility of this new glass has been
studied by using ICP-OEM and ion selective electrodes. The degradation of the glass and the formation of Fluorapatite has been followed by FTIR, XRD and solid state NMR
spectroscopy. The new glass additive forms apatite faster than the glass used in existing commercial toothpastes and is more effective in occluding the open dentinal
tubules that are the cause of tooth sensitivity. In addition the glass is very effective at re-mineralizing demineralised enamel.
The use of these glasses as re-mineralizing bioactive glass composites for tooth fillings and adhesives will be outlined
The second part of the presentation will deal with newly developed Chloride containing bioactive glasses and will look at the relationships between glass structure, and
their physical properties. The ability of the glass to crystallise to Chloroapatite and their application in toothpastes and air abrasives for cutting and polishing
teeth will be discussed.