article posted 19 May 2016
Professor Dong Qiu is current working in the institute of Chemistry, Chinese Academy of Sciences. He obtained first degree in chemistry from Beijing Normal
University, an MSc in polymer physics and chemistry from Chinese Academy of Sciences and a PhD in Chemistry from the University of Bristol. After two successive postdoctoral trainings
(with Professor Terence Cosgrove at Bristol and Professor Robert Newport at Kent, respectively), he joined his current institution and set up a research group on the composite
biomedical material research.
An alternative way to endue silicate bioactivity and its potential impact
Chen Wang, Yang Cui & Dong Qiu*
Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
Silicates with some compositions can degrade in body fluid or simulated body fluid, releasing various ions to initiate hydroxyapatite precipitation on their surface, thus showing
bioactivity. To obtain such bioactivity, the corresponding silicate will need to incorporate certain essential moieties, for example Ca, which is either achieved by melt-quenching or
through mixing of precursors in sol-gel process. Two important factors are the over saturation of surrounding fluid by ion release and the nucleation site of hydroxyapatite on surface,
which is usually the anionized surface silanol. The dissolution of bioactive silicates satisfy the above conditions. However, in conventional bioactive silicates, the calcium is normally
incorporated in the silicate network, which makes the fabrication process not suitable to produce nanoparticles with different size and size distributions. We developed a post-modification
strategy to prepare narrowly distributed bioactive silicate colloids with different size, thus could provide model systems for further studies.
Figure 1. Optical images of colloid dispersions (left) and their bioactivities (right).